Bo Chen, Jeffrey Oliver, Soumak Dutta, Grady H. Rylander III, Sharon L. Thomsen, and Ashley J. Welch, "Corneal minimal visible lesion thresholds for 2.0 μm laser radiation," J. Opt. Soc. Am. A 24, 3080-3088 (2007)
To support refinement of the ANSI Maximum Permissible Exposure safety limits, a series of experiments were conducted in vivo on Dutch Belted rabbit corneas to determine corneal minimum visible lesion thresholds for continuous-wave laser irradiation. Single pulse radiant exposures were made at specified pulse durations of 0.1, 0.25, 0.5, 1.0, 2.0, and for spot diameters of and . Threshold lesions were defined as the presence of a superficial surface whitening one hour after irradiation. Temperature measurements indicated that threshold peak temperatures were dependent on spot size and exposure duration. The exposure duration dependence of threshold average radiant exposure was described by an empirical power law equation: threshold radiant
.
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First line in each group of three is ED50 threshold power [mw] ± standard deviation.
Second line in each group of three gives fiducial limits at the 95% confidence level.
Third line shows the slope of probit curve.
Table 3
Slopes of the Linear Fits of Peak Temperature Rise with Respect to Powera
Spot Size (mm)
Exposure Duration (s)
4
2
1
0.5
0.25
0.1
1.17
0.418
0.382
0.338
0.303
0.235
0.157
4.02
0.102
0.087
0.075
0.049
0.029
0.016
That is, peak temperature rise irradiated power (mwa).
Table 4
Peak Temperature at the Spot Center for Threshold Irradiation
Ranges of peak temperatures at the spot center for threshold irradiation defined as follows: maximum peak temperature with consistent absence of damage−minimum peak temperature with consistent presence of damage.
Table 5
Results of Power-LawaFitting of Threshold Radiant Exposure
First line in each group of three is ED50 threshold power [mw] ± standard deviation.
Second line in each group of three gives fiducial limits at the 95% confidence level.
Third line shows the slope of probit curve.
Table 3
Slopes of the Linear Fits of Peak Temperature Rise with Respect to Powera
Spot Size (mm)
Exposure Duration (s)
4
2
1
0.5
0.25
0.1
1.17
0.418
0.382
0.338
0.303
0.235
0.157
4.02
0.102
0.087
0.075
0.049
0.029
0.016
That is, peak temperature rise irradiated power (mwa).
Table 4
Peak Temperature at the Spot Center for Threshold Irradiation
Ranges of peak temperatures at the spot center for threshold irradiation defined as follows: maximum peak temperature with consistent absence of damage−minimum peak temperature with consistent presence of damage.
Table 5
Results of Power-LawaFitting of Threshold Radiant Exposure