Abstract

Amorphous simvastatin (amorphous SIM) and Form I of SIM were prepared separately from SIM acetone (AC)/ethyl acetate (ETAC)/ethanol (ET) solutions by simply controlling the solvent evaporation rate, and the kinetic formation of amorphous SIM from SIM AC/ETAC/ET solutions was explained using mid-frequency Raman difference spectra analysis. The mid-frequency Raman difference spectra analysis results indicate that the amorphous phase has close connections with solutions and might be the bridge, playing an important role in the intermediate phase, between solutions and their outcome polymorphs.

© 2023 The Author(s)

Phase-shift cavity ring-down spectroscopy using mid-IR light from a difference frequency generation PPLN waveguide

Roberto Grilli, Luca Ciaffoni, and Andrew J. Orr-Ewing
Opt. Lett. 35(9) 1383-1385 (2010)

Ultrabroadband mid-infrared noncollinear difference frequency generation in a silver thiogallate crystal

Yaroslav V. Aulin, Aashish Tuladhar, and Eric Borguet
Opt. Lett. 43(18) 4402-4405 (2018)

All-fiber mid-infrared source tunable from 6 to 9 μm based on difference frequency generation in OP-GaP crystal

Jarosław Sotor, Tadeusz Martynkien, Peter G. Schunemann, Paweł Mergo, Lucile Rutkowski, and Grzegorz Soboń
Opt. Express 26(9) 11756-11763 (2018)

Process-parameter-dependent optical and structural properties of ZrO₂MgO mixed-composite films evaporated from the solid solution

N. K. Sahoo and A. P. Shapiro
Appl. Opt. 37(4) 698-718 (1998)

Using high frequency Raman spectra for colonic neoplasia detection

Michael A. Short, Isabella T. Tai, David Owen, and Haishan Zeng
Opt. Express 21(4) 5025-5034 (2013)