Abstract
Analysis of the optical intrinsic signal of an exposed cortex has been applied to measurement of functional brain activation. It is important for accurate measurement of concentration changes in oxygenated hemoglobin and deoxygenated hemoglobin to consider the wavelength dependence of the mean optical path lengths for the reflectance of cortical tissue. A method is proposed to experimentally estimate the wavelength dependence of the mean optical path length in cortical tissue from the multispectral reflectance of the exposed cortex without any additional instruments. The trend in the wavelength dependence of the mean optical path length estimated by the proposed method agrees with that estimated by the model-based prediction, whereas the magnitude of the wavelength dependence predicted by the proposed method is greater than that of the model-based prediction. The experimentally predicted mean optical path length minimizes the difference in the measured changes in the concentrations of the oxygenated hemoglobin and deoxygenated hemoglobin calculated from different wavelength pairs.
© 2007 Optical Society of America
Full Article | PDF ArticleMore Like This
Hiroshi Kawaguchi, Tatsuya Koyama, and Eiji Okada
Appl. Opt. 46(10) 1658-1668 (2007)
Matthias Kohl, Ute Lindauer, Ulrich Dirnagl, and Arno Villringer
Opt. Lett. 23(7) 555-557 (1998)
Chie Sato, Takekane Yamaguchi, Mitsuru Seida, Yoshihisa Ota, Iwae Yu, Yoshinobu Iguchi, Masahito Nemoto, and Yoko Hoshi
Appl. Opt. 46(14) 2785-2792 (2007)