Abstract
Fluorescence spectroscopy provides information about biochemical, functional, and structural changes of biomolecular complexes in tissues that occur due to either pathological transformation or therapeutic intervention [1-3]. Early detection, diagnosis, and monitoring of pathological conditions using fluorescence spectroscopy may lead to effective treatment of critical diseases including atherosclerosis and cancer. In addition, because fluorescence-based devices allow for light delivery and collection using fiber-optic probes, such fluorescence-based devices not only facilitate non- or minimally invasive investigations of tissues with catheters or endoscopic probes, but also enhance the diagnostic capability of traditional clinical devices.
© 2005 Optical Society of America
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